血清阴性脊柱关节病合并IgA肾病临床分析(附9例报告)

Analysis of seronegative spondylarthropathies complicated with IgA nephropathy (report of 9 cases)

目的提高对血清阴性脊柱关节病合并IgA肾病的认识。方法回顾分析9例血清阴性脊柱关节病合并IgA肾病患者的临床表现、肾脏病理和治疗、随诊情况。结果9例患者均为男性,平均年龄28.4岁,兼具血清阴性脊柱关节病与IgA肾病的典型临床特征,其中3例为未分化血清阴性脊柱关节病,6例为强直性脊柱炎;9例患者的肾脏病理情况轻重不一。结论IgA肾病可以为血清阴性脊柱关节病的关节外表现,早期明确诊断对指导治疗非常重要。

To investigate the clinical characteristics of patients with seronegative spondylarthroapathy complicated with IgA Nephmpathy. Methods The clinical characteristics of patients with semnegative spondylarthroapathy and IgA Nephropathy in PUMC hospital during the past seven years were retrospectively studied. Renals biopsy specimens were evaluated by light immunofluorescency and electronicmicroscopy. Results This study included 9 patients all receiving renel biopsy in whom 3 were diagnosed as undifferentiated seronegative spondylarthmapathy, 6 were ankylosing spondylitis. All 9 patients were male with the mean age of 28.4 years at onset of IgA Nephmpathy. They had typical clinical features of both seronegative spondylarthmapathy and IgA Nephropathy. Conclusious The renal involvement in patients with seronegative spondylarthroapathy can be IgA Nephmpathy. Such patients should be diagnosed early and followed uo closely.