胃CT灌注成像的初步研究

Perfusion CT of Stomach:Initial Experiences

目的:探讨16层CT进行胃CT灌注成像的可行性,评价其在胃肿瘤性病变中的价值。方法:对6例无胃疾病的患者和10例胃肿瘤患者进行了CT灌注扫描。利用胰腺模式进行灌注数据的处理。计算血流量(BF)、血容量(BV)、平均通过时间(MTT)以及表面渗透性(PS)。结果:正常胃壁的BF、BV、MTT、PS分别为(13.51±5.34)ml/(min.100g)、(3.31±1.55)ml/100g、(10.40±2.70)s、(3.70±2.86)ml/(min.100g);胃肿瘤的则为(97.32±71.04)ml/(min.100g)、(7.80±2.98)ml/100g、(10.17±3.35)s、(14.80±5.44)ml/(min.100g),P值分别为0.003、<0.001、0.856和<0.001。结论:CT灌注成像可提供胃肿瘤的血流动力学信息,在胃肿瘤的诊断中有一定价值。

Objective： To discuss the feasibility of Perfusion CT of stomach using a 16-detector CT scanner and to assess the value of Perfusion CT in the diagnosis of gastric tumors. Methods： 6 volunteers without gastric diseases and 10 patients with suspected gastric tumors underwent 16-detector Perfusion CT scan. We performed perfusion CT post-processing using pancreatic mode of Perfusion CT software. Multiple regions of interest （ROI） were selected according to stomach wall thickness on the basic images. Blood flow （BF）, blood volume （BV）, mean transit time （MTT）, and permeability surface （PS） of gastric wall were computed for every case. Results： BF, BV, MTT, and PS of gastric wall for volunteers were （13.51±5.34）ml/min. 100g, （3.31±1.55） ml/100g, （10. 40±2.70）s, （3. 70±2.86）ml/min. 100g; for gastric tumors were （97.32±71.04）ml/min·100g,（7.80±2.98）ml/100g, （10. 17± 3.35）s, （14.80±5.44）ml/min·100g respectively. The P values for perfusion CT parameters between gastric tumors and normal gastric wall were 0. 003,d0. 001,0. 856, d0. 001, respectively. Conclusion： Perfusion CT can provide hemodynamics of gastric tumors, thus playing a role in the diagnosis of gastric tumors.