利用功能磁共振研究记忆功能的研究进展

Progress in Memory Function Studied by Using fMRI

功能磁共振成像(fMRI)作为一种无创伤,可反复实验的成像技术,已被广泛地应用于各项脑功能的研究。用fMRI进行脑功能研究的主要依据是血流敏感性和BOLD对比增强原理。记忆是人脑的高级功能,其过程分为编码加工、固化、存储和提取几个阶段。大脑皮质、海马、乳头体、丘脑是参与记忆的主要解剖结构。记忆的刺激方式对各个脑区的激活是具有差异性的,记忆功能的测量和分析方法也在不断的改进。年龄和性别的不同都会对记忆能力产生影响,同时激活的脑区也会有相应的改变。此外,情感和记忆的关系正越来越受到人们的关注。本文阐述利用功能磁共振成像研究记忆功能的最新进展。

As a non-wounded and repeatedly experimental imaging technology, functional MRI （fMRI） has been used for more and more study of brain functions. The main bases of the fMRI are sensitivity of blood current and the principle of BOLD contrast enhancement. Memory is a high-grade function of human brain, which consists of encoding, solidification, storage and retrieval. Cerebral cortex, hippocampus, bulla fornicis, thalamencephalon are main constructions for memory. There are differences in the stimulus modes of memory to activations of encephalic regions. Measure and analytical methods to memory function are improving constantly. Ability of memory could be affected by age and gender, meanwhile corresponding changes emerge at encephafic regions as well. In addition, the relationship between emotion and memory is being paid attention to more and more. Progress in memory function studied by using fMRI has been reviewed in this paper.