摘要
研究了过硫酸按-TEMED体系产生的超氧负离子对健康人血液中几种生物活性物质的作用，结果表明，可以使细胞膜发生脂质过氧化作用，产生丙二醒（MDA），使生物膜造成损伤．同时使血液中超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH－PX）活性均有所降低．通过对CAT纯品的研究揭示出在血液中经SOD，的作用产生毒性更强的·OH，它是使生物膜破坏及各种酶活性降低的主要原因．
The effect of active oxygen radicals generated by ammonium persulfate-TEMED systems on several substances in healthy man's blood was investigated. The results showed that can make lipid peroxygenized ln cell membrane and MDA produced, then the biomembrane was in-jured- Meanwhile the activity of superoxide dismutase (SOD), cataase (CAT) glutathione peroxidase (GSH-PX) in the blood decreased. The study of prue CAT revealed that the produced the more toxic. OH througy its interaction with SOD, Fe2+ in blood- The existence of. OH is the main rea-son for the memberane injury and the declination of the enzyme activity.
出处
《吉林大学自然科学学报》
CAS
CSCD
1997年第2期99-102,共4页
Acta Scientiarum Naturalium Universitatis Jilinensis
基金
国家重点实验室开放实验室资助
关键词
活性氧
GSH-PX
SOD
衰老
自由基
active oxygen radical,glutathione reroxidase,catalase,superoxide dismutase
