广州地区淋球菌的耐药趋势及对策

TENDENCY AND COUNTERMEASURES OF ANTIBIOTIC RESISTANCE OF NEISSERIA GONORRHOEAE IN GUANGZHOU District

目的探讨近年我市在性病发病率持续下降情况下,淋球菌对常用抗生素的耐药趋势及可能原因,为进一步提高淋病控制水平提供参考。方法性病的流行病学资料收集自全市性病检测点,淋球菌耐药性监测资料来自每年临床淋病患者菌株的监测,使用琼脂稀释法对壮观霉素、头孢三嗪、环丙沙星、四环素进行药物敏感性实验。结果6年来我市性病年报告发病率及淋病监测发病率逐年下降,淋球菌仍保持对壮观霉素的高度敏感,但对头孢三嗪的敏感性有所下降,对环丙沙星、青霉素、四环素等几种常用传统抗生素的耐药率逐年上升。结论青霉素、环丙沙星及四环素等药物己不宜用于淋病的治疗,加强临床淋病用药指导十分必要。

Objective To investigate the tendency and the causes of antibiotic resistance of Neisseria Gonorrhoeae under the situation that STD prevalence had being decreased in the recent years, and applying reference for the control of gonorrhoea. Methods Epidemiology data of STD was collected from STD supervising spot in Guangzhou city and drugs resistence data form gonococcal strains from clinic year by year. Sensitivity to trobicin et al 4 antibiotic was tested with agar diluting procedures. Results Report of incidence of STD and gonorrhoea descended year by year. Neisseria Gonorrhoeae kept highsensitive to Spectinomycin but Ceftriaxone sensitivity descreased, antibiotic resistance to Ciprofloxacin, Benzylpenicillin and Tetracycline et al, commonly used antibiotic increased. Conclusion Ciprofloxacin, Benzylpenicillin and Tetracycline had been not suitable for the treatment of gonorrhoea. It is essential to strengthen medication instruction and administration.