氧氟沙星不同给药方案治疗下呼吸道感染的效益分析

THE BENEFIT ANALYSIS OF DIFFERENT THERAPEUTIC SCHEMES OF OFLOXACIN IN TREANTMENT OF LOWER RESPIRATORY TRACT INFECTION

目的对氧氟沙星不同给药方法治疗下呼吸道感染进行药物经济学评价。方法将67例下呼吸道细菌感染患者随机分为A、B组,A组33例,采用氧氟沙星连续静脉滴注;B组34例,采用氧氟沙星序贯治疗。观察疗效并对2种方案采用药物经济学中最小成本分析法进行比较。结果两组在临床疗效及不良反应发生率方面无显著性差异(p>0.05),但A组的费用却明显高于B组(p<0.05)。结论对于下呼吸道细菌感染患者,采用序贯治疗,不但安全、有效,而且更加经济合理。

Objective To evaluate the pharmacoeconomics outcome of 2 therapeutic schemes of ofloxactin in treatment of lower respiratory tract infections. Methods 67 patients with lower respiratory tract infections were randomly divided into Group A and Group B. Ofloxacin was given by continuous intravenous infusion in Group A with 33 patients,while it was given by sequential therapy in Group B with 34 patients. The therapeutic effects were observed and cost - minimization analysis of pharmacoeconomics was used to compare 2 therapeutic schemes. Results There were no significant differences （p 〉 0. 05 ） in the rates of effectiveness, ADR,but the treatment cost in Group A was higher thanthatinGroupB（p 〈0.05 ）. Conclusion Sequential scheme is safe ,effective, rationalandmoreeconomical.