胺碘酮与利多卡因对急性心肌梗死并室性心律失常的疗效比较

Comparison of Therapeutic Effects of Amiodarone vs Lidocaine in the Treatment of Acute Myocardial Infarction Complicated with Ventricular Arrhythmia

目的回顾性比较胺碘酮与利多卡因治疗急性心肌梗死(AMI)并室性心律失常的疗效。方法对40例AMI合并严重室性心律失常患者,给予利多卡因(利多卡因组)治疗(2000年1月至2004年6月);对30例AMI合并严重室性心律失常患者,给予胺碘酮(胺碘酮组)治疗(2004年7月至2006年12月),回顾比较两种药物对严重室性心律失常的疗效。结果胺碘酮与利多卡因对AMI并室性心律失常的疗效、室颤发生率及病死率差异均有显著性意义(均P<0.05)。结论胺碘酮治疗AMI并室性心律失常疗效显著,能明显降低AMI并室性心律失常患者室颤发生率及病死率,推荐作为治疗AMI并室性心律失常药物治疗的首选药物。

Objective To retrospectively compare the therapeutic effectiveness of amiodarone vs lidocaine in the treatment of myocardial infarction complicated with ventricular arrhythmia following acute myocardial infarction. Methods Forty patients with acute myocardial infarction （AMI） complicated with severe ventricular arrhythmia were subjected to the treatment of lido caine （lidocaine group） fore Jan. 2000 to June 2004, and those （30 cases） from July 2004 to Dec. 2006 to amiodarone （amiodarone group）. The therapeutic effectiveness in both groups was compared. Results There was significant difference in the therapeutic effectiveness of post-AMI ventricular arrhythmia, incidence of ventricular fibrillation as well as mortality between lidocaine group and amiodarone group （P〈0.05）. Conclusion The therapeutic effectiveness of amiodarone in the treatment of AMI complicated with ventricular arrhythmia was significant. Amiodarone can obviously reduce the incidence of ventricular fibrillation on the AMI patients complicated with ventricular fibrillation and mortality, and is recommended as the first choice for treating AMI complicated with ventricular arrhythmia.