头颈肿瘤患者术前血C-反应蛋白水平测定的临床意义

C-reactive protein level of patients with head and neck tumor before operation

目的:探讨头颈肿瘤患者术前血中C-反应蛋白(C-reactive protein,CRP)水平与术后感染的关系。方法:以177例晚期头颈肿瘤外科手术患者为研究对象,手术前1 d常规行血CRP、清蛋白以及白细胞计数检查,并分析术后感染的相关资料。结果:术后发生感染21例(11.9%),术前CRP水平明显高于未感染患者,两组差异有统计学意义(t=2.835,P<0.01)。术前CRP水平升高患者术后感染率为57.14%,明显高于CRP水平正常组的3.36%(χ2=6.18,P<0.01);术前CRP升高患者术后住院时间明显长于CRP正常组,差异有统计学意义(t=2.215,P<0.05)。结论:头颈肿瘤患者术前血清CRP水平升高者术后发生感染的危险明显升高。

Objective： To investigate the relationship of C-reactive protein（CRP） level of patients with head and neck tumor before operation and the infection after operation. Methods： The content of CRP, ABL and WBC in 177 patients with head and neck tumor pre-operative 1 day was determined. The data of C-reactive protein and infection after operation were analyzed by a statistical method. Results： Twenty-one patients （11.9%） had infection after operation, whose CRP level was much higher than patients without infection （ t = 2. 835, P 〈 0.01 ）. The infection rate of patients with an increased CRP level was significant higher than that with a normal CRP level （ x^2 = 6.18, P 〈 0.01 ）. Moreover, the admission period was obviously prolonged （ t = 2.215, P 〈 0.05）. Conclusion： As the serum CRP is raised in patients with head and neck tumor before operation, the infection risk significantly increases after operation.