紫杉醇对豚鼠听阈的影响

Effect of Paclitaxel on the hearing threshold in guinea pigs

目的:探讨紫杉醇对豚鼠听阈的影响。方法:将30只雌性豚鼠随机分为6组(1个对照组和5个实验组,每组5只),实验组分别予以不同剂量紫杉醇腹腔内注射,检测用药前、后各组动物ABR阈值。结果:实验组听力水平用药后均显著减低,相关分析显示,总药量与听力损失程度之间无显著相关性。结论:紫杉醇可导致轻到中度听力损失。

Objective： To investigate the effects of Paclitaxel on the hearing threshold in guinea pigs. Methods： Thirty female guinea pigs were randomly divided into one control group and five experimental groups. The control group received no medications while the five experimental groups were intraperitoneallly subjected with different doses of Paclitaxel. Prior to medication and after the ending of medication, all animals underwent auditory brainstem response （ABR） testing bilaterally. Results： Hearing levels were significantly decreased in the experimental groups. No correlation was found between the dose given and the degree of hearing loss. Conclusion： Paclitaxel causes mild to moderate sensorineural hearing loss.