上海地区艾滋病患者机会性感染的临床特征和影响预后的因素

Study on clinical features and prognostic factors in acquired immune deficiency syndrome patients with opportunistic infections in Shanghai

目的探讨AIDS患者机会性感染的临床特征和预后因素。方法用Logistic回归的方法,分析42例病原明确的AIDS合并机会性感染患者临床资料和影响患者预后的主要因素。结果细菌性感染是AIDS患者机会性感染的第1位病因,占57.1%;多种病原同时感染率为83.3%;且多个部位同时感染率为57.1%。机会性感染与CD4^+T淋巴细胞数的高低相关。结论CD4^+T淋巴细胞数是影响AIDS患者预后的最主要因素。患者的主要机会性感染与CD4^+T淋巴细胞计数的平均数密切相关。

Objective To investigate clinical features and prognostic factors in acquired immune deficiency syndrome （AIDS） patients with opportunistic infections. Methods Forty-two cases of AIDS patients with opportunistic infections were enrolled in this study. Clinical data and major factors affecting the prognosis were analyzed using Logistic regression. Results Bacterial infection was the first etiological factor（57.1% ） of opportunistic infections in AIDS patients. Eighty-three point three percent of patients infected with more than two kind of etiological agents. Fifty-seven point one percent of cases were infected in multiple sites. CD4^＋T cells count was associated with the opportunistic infections. Conclusions The CD4^＋T lymphocytes count is the key factor affecting the prognosis of AIDS patients with opportunistic infections. The average of CD4^＋T lymphocytes count is significantly related with the major opportunistic infections in AIDS paitents.