摘要
流行病学资料显示,随着总胆固醇水平的升高,冠心病死亡和发生的危险增加。但90年代初之前,降脂治疗对冠心病的疗效存在争议。围绕着这个问题,开展了大量的大样本随机对照试验。从4S到IDEAL等他汀类药物的大规模随机对照临床试验研究中,可以看到他汀类降脂治疗在冠心病二级预防中的循证历程。循证医学的精髓,在他汀类药物用于冠心病二级预防中的医学大舞台上得到了充分的展示。
Epidemiology data shows that the occurrence and death of coronary artery disease increased with the increase of blood cholesterol level. But before 1990s, disputes existed in lipid lowering therapeutics in coronary artery disease. From 4S in 1994 to IDEAL in 2005, 11 years of lots of randomized controlled clinical trials revealed plenitudinous evidence of the effectiveness and safety of lipid lowering with statins. The spirit of evidence-based medicine is wealthy showed in the use of statins on secondary prevention of coronary artery disease.
出处
《循证医学》
CSCD
2007年第4期245-246,250,共3页
The Journal of Evidence-Based Medicine
关键词
冠心病
预防
他汀类药物
循证医学
coronary heart disease
prevention
statins
evidence-based medicine
