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多因子降维法分析基因-基因交互作用的应用进展 被引量：13

Recent advances in applications of multifactor dimensionality reduction for detecting gene-gene interactions
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摘要 多因子降维法（multifactor dimensionality reduction，MDR）是近年来发展的一种分析交互作用的新方法，“因子”即交互作用研究中的变量（如基因型或环境因素），“维”是指研究的多因子组合中的因子数（如基因型数目）；该方法以疾病易感性分类（高危、低危）的方式建模，将研究中的多个因子看作一个多因子组合（基因型组合），
作者 唐迅 李娜 陈大方 胡永华
机构地区 北京大学公共卫生学院流行病与卫生统计学系流行病学教育部重点实验室
出处 《中华流行病学杂志》 CAS CSCD 北大核心 2007年第9期918-921,共4页 Chinese Journal of Epidemiology
基金 国家自然科学基金(30671807) 高等学校博士学科点专项科研基金(20060001111)
关键词 多因子降维法 病例对照研究 基因-基因交互作用 Multifactor dimensionality reductions Casecontrol study Gene-gene interactions
分类号 R363.1 [医药卫生—病理学] R346 [医药卫生—基础医学]
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参考文献29

  • 1Ritchie MD, Hahn LW, Roodi N, et al. Multifactordimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet, 2001,69(1) : 138-147.
  • 2Moore JH. Computational analysis of gene-gene interactions using multifactor dimensionality reduction. Expert Rev Mol Diagn, 2004,4 ( 6 ) : 795-803.
  • 3唐迅,李娜,胡永华.应用多因子降维法分析基因-基因交互作用[J].中华流行病学杂志,2006,27(5):437-441. 被引量：30
  • 4Cho YM, Ritchie MD, Moore JH, et al. Multifactordimensionality reduction shows a two-locus interaction associated with Type 2 diabetes mellitus. Diabetologia, 2004,47 (3) : 549- 554.
  • 5Coffey CS, Hebert PR, Ritchie MD, et al. An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation. BMC Bioinformatics, 2004,5 ( 1 ) : 49.
  • 6Williams SM, Ritchie MD, Phillips JA 3rd, et al. Multilocus analysis of hypertension: a hierarchical approach. Hum Hered, 2004,57(1) :28-38.
  • 7Tsai CT, Lai LP, Lin JL, et al. Renin-angiotensin system gene polymorphisms and atrial fibrillation. Circulation, 2004,109(13) : 1640-1646.
  • 8Bastone L, Reilly M, Rader DJ, et al. MDR and PRP: a comparison of methods for high-order genotype-phenotype associations. Hum Hered, 2004,58(2) :82-92.
  • 9Soares ML,Coelho T, Sousa A, et al. Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single gene disease. Hum Mol Genet, 2005,14 (4) :543-553.
  • 10Qin S, Zhao X, Pan Y, et al. An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. Eur J Hum Genet, 2005,13 (7) : 807-814.

二级参考文献12

  • 1Moore JH.The ubiquitous nature of epistasis in determining susceptibility to common human diseases.Hum Hered,2003,56:73-82.
  • 2Moore JH,Ritchie MD.The challenges of whole-genome approaches to common diseases.JAMA,2004,291:1642-1643.
  • 3Ritchie MD,Hahn LW,Roodi N,et al.Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer.Am J Hum Genet,2001,69:138-147.
  • 4Hahn LW,Ritchie MD,Moore JH.Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions.Bioinformatics,2003,19:376-382.
  • 5Nelson MR,Kardia SL,Ferrell RE,et al.A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation.Genome Res,2001,11:458-470.
  • 6Coffey CS,Hebert PR,Ritchie MD,et al.An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction:the importance of model validation.BMC Bioinformatics,2004,5:49.
  • 7Moore JH.Computational analysis of gene-gene interactions using multifactor dimensionality reduction.Expert Rev Mol Diagn,2004,4:795-803.
  • 8Robnik-Sikonja M,Kononenko I.Theoretical and empirical analysis of Relief F and RRelief F.Mach Lear J,2003,53:23-69.
  • 9Tsai CT,Lai LP,Lin JL,et al.Renin-angiotensin system gene polymorphisms and atrial fibrillation.Circulation,2004,109:1640-1646.
  • 10Hahn LW,Moore JH.Ideal discrimination of discrete clinical endpoints using multilocus genotypes.In Silico Biol,2004,4:183-194.

共引文献29

同被引文献180

引证文献13

二级引证文献74

中华流行病学杂志
2007年 第9期

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