重庆市2005年乙型病毒性肝炎血清流行病学调查

Seroepidemiological Invetigation and Analysis on Virus Hepatitis B in Chongqing

目的了解重庆市1～59岁人群乙型肝炎(乙肝)病毒(HBV)感染现状,为制订预防控制策略提供依据。方法采用多阶段分层随机抽样的方法,抽取3 251人进行血清流行病学调查,用固相放射免疫法进行检测。结果重庆市1～59岁人群乙肝病毒表面抗原(HBsAg)、乙肝病毒表面抗体、乙肝病毒核心抗体、HBV阳性率经标化后分别为10.35%、33.47%、47.72%、51.94%,男、女性人群HBsAg阳性率分别为13.14%、9.85%,城乡人群HB-sAg阳性率分别为9.11%、12.49%。HBsAg阳性人群中,乙肝病毒e抗原标化阳性率为39.31%。结论重庆市乙肝疫苗纳入儿童计划免疫管理10余年,1～14岁儿童HBV感染率大幅度下降。

Objective To know about the epdemic situation of virus hepatitis B in Chongqing and provide theoretic basis for the prevention of the hepatitis B. Methods Stratified clustered-random sampling in different stages were adapted in this study. A total of 3251 residents aged from 1-59 years old were surveyed with questiormaire and were made blood test. HBsAg,antibody of H/Ks,and antibody of HBc were detected with SPRIA method,HBeAg and anti-HBe were detected with ELISA method. Results The adjusted rate of HBsAg, anti-HBs,anti-HBc and HBV is 10. 35%,33. 47%,47. 72%, and 51.94%,respectively. Among the people of HBsAg positive, the adjusted rate of HBeAg is 39. 31%. The rate of HBsAg is 13. 14% in male and 9. 85% in female,the rate is 9. 11% in urban area and 12. 49% in rural area. Conclusion The result revealed some epdemic characters of hepatitis B in Chongqing and suggested that since the hepatitis B vaccine was brought into EPI more than ten years, HBV infection rate had been decreased in children（〈15 yeas old）.