血压参数与老年人认知功能障碍的关系

Relationship Between Blood Pressure Parameters and Cognitive Impairment in Elderly People

目的探讨血压参数与老年人认知功能障碍之间的关系。方法对开滦集团公司1063名离退休职工进行健康查体,同时进行简易精神状况检查表(MMSE)测试以评价认知功能,资料完整并符合入选标准的共计890例,认知功能障碍者作为病例组222名,非认知功能障碍者为对照组668名。测定血压并进行统计学分析。结果病例组收缩压(SBP)、脉压(PP)、脉压指数(PPI)均高于对照组(P<0.05);病例组舒张压(DBP)低于对照组(P<0.05)。线性趋势检验分析中随SBP、PP、PPI的增高,认知功能障碍的患病率增加(P<0.05);随DBP的增高,认知功能障碍的患病率下降(P<0.05)。结论SBP、PP、PPI增加,DBP下降与认知功能障碍有关。

Objective To explore the relationship between blood pressure parameters and cognitive impairment in elderly people.Methods 890 retired workes of Kailuan Coal Mine were surveyed with questionnaires.The cognitive function was evaluated by mini-mental state examination（MMSE）.222 cognitive impairment patients were categorized as case group,668 healthy subjects served as control group.Blood pressure and the related indexs were determined.Results The systolic blood pressure（SBP）,pulse pressure（PP）and pulse pressure index（PPI）in the case group were higher than control group（all P〈0.05）with lower diastolic blood pressure（DBP）（P〈0.05）.Linear regression analysis showed SBP,PP and PPI were positively related with the morbidity of cognitive impairment（P〈0.05）,with DBP negatively related with the morbidity of cognitive impairment（P〈0.05）.Conclusion Increases in SBP,PP,PPI and decreases in DBP were associated with cognitive impairment.