高血压患者动脉硬度指数与颈动脉内膜-中膜厚度、斑块的关系

The Arterial Stiffness Index and Intima-media Thickness Plaque of Carotid Arteries in Hypertensive Patients

目的进一步了解动脉硬度指数(ASI)定量检测动脉硬化程度的可靠性。方法用YF-1血管硬度测量仪测量87例高血压病人的ASI,并用高频超声测量其颈动脉内膜-中膜厚度(IMT)和斑块。结果(1)ASI与IMT呈正相关:r=0.395,P<0.01,ASI正常组(0～70)、轻度升高组(71～120)、中度升高组(121～180)和重度升高组(>180)的IMT值依次为(0.74±0.13)、(0.88±0.12)、(0.94±0.12)和(0.97±0.15)mm,后3组与正常组的IMT比较,差异均有非常显著意义(P<0.01)。(2)0级斑块组ASI值为(120.1±57.7)、1级斑块组ASI值为(124.1±48.3)、2级斑块组ASI值为(158.6±49.8)和3级斑块组ASI值为(204.7±47.0),2级斑块组和3级斑块组的ASI高于0级斑块组(P<0.01),3级斑块组的ASI高于1级斑块组(P<0.05)。结论ASI是一个较好的检测动脉硬化的指标。其应用价值尚需较大规模临床人群验证。

Objective This study was designed to verify whether arterial stiffness index determined by YE-1 XGYD device could be a marker for arteriosclerosis.Methods Intima-media thickness and plaque of carotid arteries were determined with high-resolution ultrasound.ASI was measured with YF-1XGYD device in 87 hypertensive subjects.Results（1）The IMT of ASI normal group（0-70）,mild elevation group（71-120）,medium elevation group（121-180）and high elevation group（〉180）were 0.74±0.13,0.88±0.12,0.94±0.12 and 0.97±0.15 mm,respectively.ASI was positively related with IMT（r=0.395,P〈0.01）.The IMT of mild elevation group,medium elevation group and high elevation group were significantly higher than that of normal ASI group（P〈0.01）.（2）The ASI of plaque grade 0,1,2 and 3 groups were 120.1±57.7,124.1±48.3,158.6±49.8 and 204.7±47.0,respectively.The ASI of plaque grade 2 and 3 groups were significantly higher than that of plaque of grade 0 group（P〈0.01）.Conclusion Arterial stiffness index may serve as a marker for detecting arteriosclerosis.Clinical study with large series of normal healthy people and patients to further determine its reliability are warranted.