骨肽注射液致过敏性休克

Anaphylactic shock caused by ossotide injection

40岁男性患者左拇指骨折,静脉滴注骨肽注射液50mg,1次/d。第6天在滴注过程中,患者突发胸、腹、腰部剧痛,T39℃,全身发绀、呼吸困难,2h后BP由入院时140/110mmHg下降到70/50mmHg,意识不清,大小便失禁;即刻停止滴注骨肽,并进行抗休克治疗,1h后症状缓解,BP100/70mmHg,R20次/min。

A 40-year-old man with fi＇acture of left thumb was given intravenously ossotide injection 50 mg once daily. On day 6 during the infusion, the patient suddenly developed severe thoracalgia, abdominalgia, and lumbago, a fever （T 39 ℃）, generalised cyanosis, and dyspnea. Two hours later, his blood pressure was decreased fi＇om 140/110 mmHg on admission to 70/50 mmHg, accompanied by unconsciousness and gatism. After discontinuation of ossotide injection instantly, he received antishock therapy. One hour later, he recovered. His blood pressure was 100/70 mmHg and respiration rate was 20 breaths/min.