摘要
1名34岁女性,因患甲状腺功能亢进,口服丙硫氧嘧啶(PTU)100mg,3次/d,地西泮10mg,3次/d。服药19d后出现发热(T38.3℃)、皮疹、咽痛、恶心等症状。实验室检查示:WBC1.18×109/L,中性粒细胞计数0.50×109/L,ALT457U/L,AST120U/L,Glu8.49mmol/L。停用丙硫氧嘧啶,给予还原型谷胱甘肽、水飞蓟宾葡甲胺、氯雷他定、地西泮、非格司亭治疗。4周后患者血常规恢复正常,肝功能明显好转。
A 34-year-old woman with hyperthyroidism was given propylthiouracil 100 mg thrice daily and diazepam 10 mg thrice daily. Nineteen days later, she developed a fever （T 38.3 ℃）, skin rash, pharyngodynia, nausea, and so on. Laboratory test revealed： WBC count 1.18× 10^9/L, neutrophile granulocyte count 0.50× 10^9/L, ALT level 457 U/L, AST level 120 U/L, blood glucose level 8.49 mmol/L. Propylthiouracil was withdrawn. The patient was treated with reduced glutathione, silybin meglumine, loratadine, diazepam, and filgrastim. After 4 weeks of therapy, the patient＇s blood routine returned to normal limits and her liver function obviously improved.
出处
《药物不良反应杂志》
2007年第4期280-281,共2页
Adverse Drug Reactions Journal
关键词
丙硫氧嘧啶
粒细胞缺乏
肝损害
propylthiouracil
agranulocytosis
hepatic injury
