摘要
1名55岁女性,因患2型糖尿病给予格列美脲2mg,1次/d早餐前0.5h口服。服药3d后,出现眩晕。经颅彩色多普勒超声(TCD)检查示:脑动脉硬化、椎-基底动脉供血不足。给予氟桂利嗪、地芬尼多、东莨菪碱抗眩晕治疗,但疗效欠佳。抗眩晕治疗3d后因血糖升高,格列美脲加量为4mg/次。服药1h后患者眩晕加重,伴恶心、呕吐,次日未能口服该药,眩晕当晚减轻,4d后消失。再次口服格列美脲4mg,1h后又出现眩晕,停用格列美脲28h后眩晕症状消失。
A 55-year-old woman with type 2 diabetes mellitus took glimepiride 2 mg once daily at half hour before breakfast. Three days later, she developed vertigo. A TCD examination revealed cerebral arteriosclerosis and vertebra-basilar artery insufficiency. She was received anti-vertigo therapy with flunarizine, difenido, and scopolaline. But the efficacy of the therapy was not apparent. After 3 days of therapy, the dose ofglimepiride was increased to 4 mg once daily for increased blood glucose. After one hour of administration, her vertigo was aggravated, and accompanied with nausea and vomit. Because the patient could not take glimepiride, the vertigo was relieved at night of the next day and disappeared 4 days later. One hour of using glimepiride again later, the vertigo was recurred. Glimepiride was stopped. 28 hours later, the patient＇s symptoms of vertigo disappeared.
出处
《药物不良反应杂志》
2007年第4期288-288,共1页
Adverse Drug Reactions Journal
关键词
格列美脲
眩晕
glimepiride
vertigo
