辛伐他汀对血液透析患者微炎症状态的影响

Influence of Simvastatin on Inflammation in Patients with Hemodialysis

目的:探讨辛伐他汀对血液透析患者炎症因子水平的影响。方法:56例稳定的血液透析患者为研究对象,以28例健康志愿者为对照组,治疗组患者分别于治疗前及辛伐他汀治疗8周后,空腹抽血查血脂,包括总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)和甘油三酯(TG),检测炎症指标:血清高敏C反应蛋白(Hs-CRP)、白介素6(IL-6)和白介素10 (IL-10),对照组进行上述相同的检查,并与对照组基础值进行比较。结果:与健康对照组比较,血液透析患者存在高血脂和微炎症状态,二者密切相关;经过辛伐他汀治疗8周后,血液透析患者的血清TC、LDL明显下降,而HDL明显上升,结果具有显著意义;经过辛伐他汀治疗8周后,炎症因子Hs-CRP和IL-6水平显著降低,而抗炎因子水平显著升高与治疗前比较,差异有统计学意义,P<0.05和P<0.05。结论:辛伐他汀对血液透析患者有显著的降脂和抗炎作用。

To explore the influence of short term treatment of simvastatin on inflammation in patients with hemodialysis. Method： Fifty-six stable hemodialysis patients were divided into two group ：T group and UT group. A another 28 health volunteers as controls. Some serum examinations which included TC ,TG and LDL-C,HDL-C some inflammatory marks such as high sensitivity Creactive protein（hs-CRP）, IL-6 and IL-10 were performed in the patients before and after 8 weeks treatment of simvastatin and in the controls. Result： Compared with the controls, high lipidemia and inflammation status were existed on hemodialysis patients,and there was a close relationship between them. After treatment of simvastatin 8 weeks,the TC, TG and LDL-C were declined significantly and the HDL-C rraised significantly （ P〈0.05 ）. Inflammatory factor such as hs-CRP and IL-6 declined significantl P〈0.05 and P〈0.05 respectively, and the anti inflammatory factor IL-10 was raised significantly（P〈0.05）. Conclusion： There is significant anti lipidemic and anti inflammaory effects of simvastatin in hemodialysis patients.