TSGF与AFP对原发性肝癌的诊断特异性、灵敏度分析

An Analysis of Specificity and Sensitivity of Diagnosis on Primary Hepatic Carcinoma by Detecting TSGF and AFP

分析探讨TSGF与AFP检测在原发性肝癌诊断中的特异性和灵敏度,以及对原发性肝癌的早期诊断价值.采用分光光度法检测TSGF,包括87例原发性肝癌(男性54例、女性33例、平均年龄67岁)、67例继发性肝癌(男性42例、女性25例、平均年龄63岁),同时用化学发光法检测AFP.对照检测179例肝病患者的TSGF、AFP(肝硬化患者74例、慢性乙型肝炎105例).其结果TSGF对原发性肝癌的敏感性(86.2%)高于AFP(71.4%)有显著性差异(P<0.05);TSGF对继发性肝癌的敏感性(88.1%)高于AFP(35.8%)有显著性差异(P<0.05);二者联合检测敏感性提高至94.3%.由此证明TSGF对恶性肿瘤的检测兼有早期性和广谱性,对原发性肝癌其灵敏度高于AFP,特异性低于AFP.二者联合检测显著提高对原发性肝癌诊断的特异性和灵敏度,对原发性肝癌早期诊断有重要的参考价值.

Our objective is to analyze the specificity and sensitivity of diagnosis on primary hepatic carcinoma by detecting TSGF and AFP. The level of TSGF was detected by the spectrophotometric method applied to 87 primary hepatic carcinoma patients （male： 54, female. 33, average age. 67） and 67 secondum hepatic carcinoma patients （male： 42, female. 25, average age. 63）. Meanwhile, the level of AFP was detected by the chemiluminescence method, and the level of TSGF and AFP were detected in 179 hepatopathy cases （hepatic cirrhosis： 74, chronic type B hepatitis. 105） as comparison. The results show： the sensitivity （86. 2%） of diagnosis on primary hepatic carcinoma by detecting TSGF is higher than that （71.4%） by detecting AFP, which is statistically significant （P〈0. 05）. The sensitivity （88. 1%） of diagnosis on secondum hepatic carcinoma by detecting TSGF is higher than that （35.8%） by detecting AFP, which is statistically significant （P〈0.05）. The sensitivity is up to 94. 3% by a combination of TSGF and AFP. Therefore it is concluded that TSGF is featured both with inchoate and universal for malignancy detection, and for primary hepatic carcinoma, the sensitivity of TSGF is higher than that of AFP, and its specificity is lower than that of AFP. The combination of TSGF and AFP will increase remarkably the sensitivity and specificity of diagnosis on primary hepatic carcinoma, and will have an important value to diagnosis on the pristine primary hepatic carcinoma.