氟西汀治疗酒依赖的临床研究

The clinical study in the treatment of alcohol dependence with fluoxetine

目的研究氟西汀在酒依赖临床治疗中的疗效。方法用氟西汀分别对酒依赖组(1)和酒依赖组(2)(HAMD量表评分>20分组和≤20分组)进行12周随访治疗,用安慰剂对酒依赖组(3)(HAMD量表评分≤20分)进行12周随访治疗;对酒依赖复发率进行评定。结果酒依赖组(1)和酒依赖组(2)复发率分别为21.88%和38.71%有显著差异(P<0.05)。结论氟西汀在酒依赖临床治疗中对酒依赖伴抑郁者有更好的治疗效果。

Objective To study the efficacy of fluoxetine in the treatment of alcohol dependence. Methods 95 male patients who met the diagnostic criteria for alcohol dependence were assigned to three groups. The patients of the alcohol dependence group 1 （HAMD - 24 score 〉 20） and the alcohol dependence group 2 （ HAMD - 24 score ≤ 20） were treated with fluoxetine for 12 weeks and the patients of the alcohol dependence group 3 （ AMD score≤20） were treated with placebo for 12 weeks. The recurrence rates of alcohol dependence were assessed. Result There was significant difference of recurrence rate between the alcohol dependence groupl and the alcohol dependence group 2 （ 5（2 = 3.13, P 〈0.05） which were 21.88% and 38.71% respectively. Conclusion fluoxetine is more effective in the treatment of alohol dependence combined with depression patients.