小剂量米非司酮治疗围绝经期子宫肌瘤的临床观察

Clinical Observation on Peri-menopause Hysteromyoma with Small Dose Mifepristone

目的探讨小剂量米非司酮治疗围绝经期有症状的子宫肌瘤的临床效果。方法将20例围绝经期有症状的子宫肌瘤患者进行药物治疗,每晚睡前口服米非司酮12.5 mg,1次/d,连服3个月为1疗程。治疗前及治疗3个月后均行阴道探头B超监测子宫、子宫肌瘤的大小、子宫内膜厚度、并检测雌激素(E2)、孕激素(P)、血常规、尿常规、肝肾功能。结果20例患者在治疗期间均闭经,15例病人绝经,子宫及子宫肌瘤体积均明显缩小,子宫内膜萎缩,贫血得以纠正。结论小剂量米非司酮治疗围绝经期有症状的子宫肌瘤疗效好,副作用小,减少了手术带来的经济及心理负担,病人依从性高,是一种值得推广的治疗方法。

Objective To discuss the clinical effect on peri - menopause hysteromyoma with small dose mifepristone. Methods 20 eases of such patient with symptom were treated with 12.5 mg mifepristone qd for 3 months as a course, The B ultrasound, uterus, hysteromyoma, endomembrane thickness, E2, P, Lab data were observed and compared. Results 20 cases had menostasis and 15 cases had menopause with smaller uterus, hysteromyoma and endornembrane thin, without anemia. Conclusion This method might have good effect with less side effect and decrease the economic and psychological burden. It should be widely used in clinic.