慢性乙型肝炎患者肝组织中HBsAg、HBcAg的表达与血清HBV-DNA含量的关系

The relationship between the expression of HBsAg and HBcAg in the liver tissue and the content of HBV-DNA in serum of patients with chronic hepatitis B

目的探讨慢性乙型肝炎患者肝组织中HBsAg和HBcAg的表达与血清HBV-DNA含量的关系。方法选择慢性乙肝患者51例,在抽取血液做HBV-DNA检测时,并行肝穿刺取肝组织。应用PCR法检测乙肝患者血清HBV-DNA的含量,应用免疫组化法检测乙肝患者肝组织中HBsAg和HBcAg的表达。结果肝组织中HBcAg的表达强度与血清HBV-DNA含量有明显正相关,肝组织中HBsAg的表达强度与血清中HBV-DNA含量只表现较弱的相关性。结论将肝组织中HBsAg和HBcAg的表达程度结合血清HBV-DNA含量作为抗病毒治疗比单一指标更可靠。

Objective To discuss the relationship between the expression of HBsAg and HBcAg in the liver tissue and the content of HBV - DNA in serum of patients with chronic hepatitis B. Methods 51 patients with chronic hepatitis B were choose randomly and detected by the content of HBV - DNA, and the expression of HBsAg and HBcAg in liver tissue of the patients. Results There were positive correlation between the expressive intensity of HBcAg in liver tissue and the content of HBV - DNA in serum, the correlation between the expressive intensity of HBsAg in liver tissue and HBV - DNA in serum is feeblish. Conclusion It is more reliable to take the expressive degree of HBsAg and HBcAg in liver tissue combining the content of HBV - DNA in serum as antivirus therapeutical indexes than single one.