摘要
目的:探讨肺心通对慢性肺源性心脏病(CPHD)模型大鼠的治疗效果及作用机理。方法:Wistar大鼠用野百合碱(MCT,60 mg.kg-1)1次腹腔注射复制CPHD大鼠模型,以肺心通混悬液治疗,21 d后,行支气管肺泡灌洗液(BALF)细胞总数及分类计数,测定大鼠血清、肺组织匀浆、肺泡灌洗液(BALF)中白介素8(IL-8)、肿瘤坏死因子α(TNF-α)的含量,肺组织切片在光镜、电镜下观察病理形态改变。结果:经治疗后,肺心通混悬液对上述检测指标的水平有明显抑制作用(P<0.01或P<0.05),在光、电镜下观察对大鼠肺血管内皮细胞的损伤有一定的修复作用。结论:肺心通药物对CPHD大鼠有较好的治疗作用。
Objective：To research the effect and the mechanism of Feixintofig on rat model of chronic pulmonary heart disease （CPHD）. Methods：50 Wistar rats were randomly divided into five groups. Rats were given a single injection of monocrotaline（MCT,60μg/g）to induce the model of CPHD. The Feixintong groups were treated by suspension in 21 days, then total white cell counts and differential counts and interleukin-8（IL-8）and tumor necrosis factor-α（TNF-α）were examined. Lung organism slices were observed with microscope. Results： The examined items of the Feixintong groups were lower than the model groups （P 〈 0.01 or P 〈 0.05）, endotheliocytes were repaired by Feixintong. Conclusions： Feixintong has good efficacy for treatment of rat model of CPHD.
出处
《中国实验方剂学杂志》
CAS
2007年第9期37-40,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
甘肃省中医管理局(2004-GZK-07)
