精制藿胆方抗过敏药理作用研究

A Pharmacological Study on the Anti-allergy Effects of Refined Huodan Recipe

目的:研究精制藿胆方及其拆方抗过敏药理作用。方法:对卵蛋白(OA)致敏豚鼠离体回肠肌过敏性收缩反应(Schultz-dale反应)、大鼠被动皮肤过敏反应(PAC)和2,4-二硝基氯苯所致小鼠耳廓皮肤迟发型超敏反应,探讨精制藿胆方抗过敏作用。结果:精制藿胆方及其拆方,对OA致敏豚鼠离体回肠肌具有快速抑制过敏性收缩作用,对大鼠被动皮肤过敏反应具有明显的抑制作用,对2,4-二硝基氯苯所致小鼠耳廓皮肤迟发型超敏反应有明显的抑制作用。广藿香油、猪胆粉两药配伍存在极显著的交互作用。结论:精制藿胆方具有显著的抗过敏作用。

Objective：To study anti-allergy effects of Refined Huodan Recipe and its disassembled prescriptions. Methods： Extracorporeal ileum muscles＇ hypersensitive contractility reaction of Guinea pig sensitized by albumin, homogeneous passive cutaneous anaphylaxis in rat, auricle cutaneous forme tardive supersensitivity action by 2, 4- dinitrochlorobenzene in mouse were used to determine the anti-allergy effect of Refined Huodan Recipe and its disassembled prescriptions. Results： Refined Huodan Recipe and its disassembled prescriptions had obvious inhibitory action on extracorporeal ileum muscles＇ hypersensitive contractility reaction of Guinea pig sensitized by albumin, homogeneous passive cutaneous anaphylaxis in rat, auricle cutaneous forme tardive supersensitivity action by 2, 4- dinitrochlorobenzene in mouse. Oleum pogostemonis and Pulvis fellis suis showed remarkable interaciton. Conclusions： Refined Huodan Recipe and its disassembled prescriptions have remarkable anti-allergy effects.