摘要
目的探讨结肠癌组织中CD44s和COX-2蛋白表达及其与临床病理参数的关系。方法采用微波-链霉亲和素生物法(LSAB)免疫组织化学染色方法检测58例结肠癌组织中CD44s和COX-2的表达情况并分析其与结肠癌浸润转移的关系。结果阳性表达物质CD44s主要在细胞膜和细胞质,COX-2主要在细胞质。58例结肠癌CD44s和COX-2蛋白阳性表达率分别为70%和67%。与肿瘤临床Dukes分期、浸润程度、淋巴结转移及术后复发密切相关(P<0.05)。结论分别检测CD44s和COX-2蛋白表达对了解结肠癌的生物学行为和判断患者的预后有一定的实用价值。
Objective To explore the expression of CD44s and COX-2 in coloreetal carcinoma and their relation to clinic-pathological factors. Methods Microwave and LSAB immunohislochemistry was carried out to detect the expression of CD44s and COX-2 in 58 cases of colorectal carcinoma, and then analyze their relation to invasion and metastasis. Results The positive rate of the expression of CD44s and COX-2 was 70.0% and 67.2% respectively, which was also closely related to tumor＇s Dukes grade, inva.sive degree, lymph node metasasis and recurrence （P 〈 0.05 ）. Conclusion Detecting the expression of CD44s and COX-2 had some practical value to understand the biological behavior of eolorectal carcinoma and to estimate the prognosis.
出处
《山西医药杂志》
CAS
2007年第9期778-780,共3页
Shanxi Medical Journal
