酒精性肝硬变病人的肝移植

Liver transplantation for the patient with alcoholic cirrhosis

５例终末期酒精性肝硬变病人在香港大学玛丽医院肝胆外科施行原位肝移植手术。男４例，女１例。年龄４１～５５岁，平均４６８岁。病人均经心理医学医生评估适合作肝移植，并且在肝移植前至少戒酒６个月。供肝全部来自脑干死亡病人。供肝灌注和保存应用ＵＷ液。４例肝移植术中应用静脉转流技术，１例采用Ｐｉｇｇｙｂａｃｋ法。术后应用类固醇、硫唑嘌呤和环胞霉素Ａ作免疫抑制治疗。移植肝脏和患者的存活率均为１００％，并已分别生存６月～３年，情况良好。肝移植可使末期酒精性肝硬变病人延长生命和恢复正常生活。

Orthotopic liver transplantations (OLT) were performed in 5 patients with end staged alcoholic cirrhosis at Queen Mary Hospital, Hong Kong The mean age of the patients was 46 8 years (range: 41～55 years) All patients had been assessed psychologically to be fit for OLT and had abstained from alcohol for at least 6 months The liver grafts came from 5 adult brain stem dead patients The organs retrieval operation from donors were performed in the standard manner using University of Wisconsin solution as the preservation solution OLT with veno venous bypass was employed in 4 cases and Piggyback method in 1 patient The post operative immunosuppressive regimen consisted of steroid, azathiopine and cyclosporine A Both the overall graft and patient survival rates were 100% All patients have been alive at 6 months to 3 years Liver transplantation can prolong the life of end staged alcoholic cirrhotic patients and recover to normal life