固定化青霉素酰化酶合成头孢拉定的工艺研究

Synthesis of Cephradine with the Immobilized Penicillin Acylase

用7-氨基-3-脱乙酰氧基头孢霉烷酸和2,5-二氢苯甘氨酸甲酯盐酸盐在磷酸盐缓冲液体系中(20℃,pH 7.0),利用固定化青霉素酰化酶催化合成抗生素头孢拉定,收率90%。

Cephadine was synthesized from 7-ADCA and DHME in the phosphate buffer （20℃, pH 7.0） with the immobilized penicillin acylase as a catalyst in a yield of 90%.