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脂毒性心肌病的发病机制及治疗进展 被引量：2

Pathogenesis and Therapy of Lipotoxic Cardiomyopathy
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摘要 心肌游离脂肪酸的摄入和利用的失协调导致心肌中脂质积聚并进而引起脂毒性心肌病。脂质通过何种机制导致心肌功能的改变,以及如何来干预脂毒性心肌病成为当今心血管领域倍受关注的研究方向。现就脂毒性心肌病的发病机制及治疗进展做一综述。 ： Mismatches between myocardial fatty acid uptake and utilization lead to the accumulation of cardiotoxic lipid species, and cause lipotoxic cardiomyopathy. Recent cardiovascular research has focused on how lipid accumulation contributes to cardiomyopathy, and on how lipotoxic cardiomyopathy can be prevented. This article discusses the mechanisms of pathogenesis and therapy of lipotoxic cardiomyopathy.
作者 李传保 卜培莉
机构地区 教育部和卫生部心血管重构和功能研究重点实验室山东大学齐鲁医院急诊科 教育部和卫生部心血管重构和功能研究重点实验室山东大学齐鲁医院心内科
出处 《心血管病学进展》 CAS 2007年第5期774-776,共3页 Advances in Cardiovascular Diseases
关键词 游离脂肪酸 脂毒性 细胞凋亡 瘦素 free fatty acid lipotoxic apoptosis leptin
分类号 R542.2 [医药卫生—心血管疾病]
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参考文献18

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同被引文献27

  • 1廖玉华,余淼,史河水.心外膜脂肪组织:心血管病防治的新靶点[J].临床心血管病杂志,2020,36(1):11-14. 被引量：16
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  • 7Xu J,Kimball TR,Lorenz JN,et al.GDF15/MIC-1 functions as a protective antihypertrophic factor released from the myocardium in association with SMAD protein activation[J].Circ Res,2006,98(3):342-350.
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心血管病学进展
2007年 第5期

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