新型血管紧张素Ⅱ1型受体拮抗剂奥美沙坦的内皮保护作用

Protective Effect of New Angiotensin-Ⅱ Subtype 1 Receptor Antagonist Olmesartan Medoxomil on Endothelial Function

奥美沙坦是一种新型血管紧张素Ⅱ1型受体拮抗剂,近年研究表明除了稳定、持久的降压作用外,它还可通过抑制氧化应激、抑制血管微炎症反应、增加循环内皮祖细胞数量等机制发挥内皮保护效应。现综述了该药对血管内皮功能的保护作用及可能机制。

Olmesartan medoxomil is a new angiotensin Ⅱ subtype 1 receptor antagonist. Apart from its stable, persistent antihypertensive effects, olmesartan medoxomil also has protective effects on endothelial function which may be caused by anti-oxidative stress, inhibition of vascular microinflammation, increase of endothelial progenitor cells, and by other mechanisms. This review summarizes its protective effects and possible meehanism on endothelial function.