坏死性胰腺炎的持续损害因子——胰腺缺血

Pancreatic ischemia:a contineous injury factor in acute necrotic pancreatitis

作者应用大鼠坏死性胰腺炎模型，探讨胰腺缺血在坏死性胰腺炎疾病的全过程中是否是持续损害因子。检测五组大鼠血浆内血栓素Ｂ２（ＴＸＢ２）、前列腺素Ｆ１α（ＰＧＦ１α）的浓度及血清内血管紧张素转化酶（ＡＣＥ）的活性。结果表明，实验组的ＴＸＢ２、ＰＧＦ１α与对照组皆有显著差异性（Ｐ＜０．０５）。ＡＣＥ，除６小时的活性低于对照组（两者无差异）外，其它实验组显著高于对照组（Ｐ＜０．０５）。由上推测，导致坏死性胰腺炎缺血的因素持续存在。因此，胰腺缺血是坏死性胰腺炎的持续损害因子，既是起始因子，又是恶化因子，且不可能出现再灌注损伤现象。

ANP model in rats was used to determine the concentration of TXB 2,PGF 1α in plasma and the ACE activity in serum in five groups.The concentration of TXB 2,PGF 1α in all experimental groups was significantly different from that of control group ( P <0.05). The comparison of ACE activity was just the same as the above except that of 6h.The factors leading to pancreatic ischemia functioned continously. We conclude that pancreatic ischemia is a continous injury factor in ANP,and there is no reperfusion injury in the course of the disease.