精索静脉曲张不育症发病机理探讨与综合疗效观察

Pathogenesis and combined treatment of sterility in men with varicocele

为探讨精索静脉曲张不育症的发病机理，总结综合治疗的经验。作者对２１例患者睾丸标本行电镜观察及临床分析。结果显示：本组经手术及药物综合治疗，术后二年１６例（７６．２％）致孕。睾丸支持细胞有糖原浸润，生精过程障碍以中晚期最著。结论：睾丸中碳水化物和能量代谢障碍是精索静脉曲张不育症发病机理的重要环节，手术治疗与药物治疗配合，有利提高致孕率。

To investigate the pathogenesis of sterility in men with varicocele and summarize the effects of combined treatment,we anallyed ultrastructure of testicular specimens in 21 cases. With combined surgical and medicinal treatment,16 men (76 2%) made their wives pregnant during a period of 2 years after the operation.Electron microscopy disclosed glycogen infiltration of sertoli cells,and decreased spermatogenesis especially involving the middle and late stages.Defective carbohydrate and energy metabolism in the testis is suggested as the key point in the pathogenesis of sterility,and a combined surgical and medicinal treatment is beneficial to the increase of pregnant rate.