生物粘合剂对胆肠吻合口瘢痕形成的影响

Influence of fibrin glue on biliointestinal anastomotic scar formation

为了克服丝线缝合组织加重瘢痕形成之不足，作者用生物粘合剂（ＦＧ）替代缝线，结合内支撑导管建立了各种胆肠吻合口瘢痕动物实验模型，并定期对吻合口瘢痕组织进行病理形态学观察和计算机图像处理（ＥＣＶＤ），从瘢痕形成的角度观察胆肠吻合口愈合过程。结果表明，ＦＧ可促进伤口愈合、减少瘢痕形成、加速瘢痕成熟软化；内支撑保留６个月瘢痕成熟。作者认为，ＦＧ克服了丝线缝合加重瘢痕形成的不足，是预防术后胆道狭窄的一种有效措施。

Conventional suture technique in the reconstruction of the bile duct often result in anastomotic stenosis and eventual obstructive jaundice and biliary cirrhosis.To overcome the aforementioned drawbacks,fibrin glue(FG)was used instead in the biliointestinal anastomosis where indwelling stent was inserted to complete the exeperimental model. The experiment consisted of pathological study and ECVD evaluation of anastomotic specimens in order to follow up the whole process of anastomotic wound healing.The experimental studies dis closed that FG promotes wound healing,limits scar formation, and accelerates scar softening and maturnation. FG plus 6 month indwelling stent can guarantee scar maturation. It is an effective method in the prevention of bile duct stricture.