新诊断的Ⅱ型糖尿病患者胰岛β-细胞胰岛素分泌功能的测定

The Study on Insulin Secretion Function of β cell in New Diagnosed Type Ⅱ Diabetic Patients

为观察Ⅱ型糖尿病患者胰岛β－细胞功能的变化，采用口服及静脉萄萄糖负荷方法，测定了３０例初发的Ⅱ型糖尿病患者胰岛β－细胞Ⅰ相及Ⅱ相胰岛素分泌功能，并与正常对照组３０例比较。结果发现：新诊断的Ⅱ型糖尿病患者其胰岛β－细胞的Ⅰ相分泌功能缺如，Ⅱ相分泌功能降低且与血糖高峰不同步。认为Ⅱ型糖尿病患者胰岛β－细胞分泌胰岛素不足以及胰岛素分泌的脉冲现象减弱，可能是Ⅱ型糖尿病患者血糖升高的主要原因。

To determine type Ⅱ diabetes in association with alteration in β cell function,we studied 30 patients with newly diagnosed diabetes and 30 matched controls.The β cell 1st phase insulin response was measured by intravenous glucose tolerance test and the 2nd phase insulin response was measured by oral glucose tolerance test.The results revealed that in type Ⅱ diabetes mellitus the pulse of 1st phase insulin secretion could not be found.The amount of 2nd phase insulin secretion of the patients was lower than that normal controls,and the patients' secretary pulse of insulin was not concomitant with glucose pulse.These findings again suggest it is the defect in β cell function,not the peripheral resistance an essential cause of overt type Ⅱ diabetes.