骨碱性磷酸酶检测对早期筛查新生儿佝偻病的临床研究

A CLINICAL STUDY ON THE EARLY DETECTION OF BONE ALKALINE PHOSPHATASE IN NEONATAL RICKETS

为了解新生儿佝偻病发病情况，我们检测了107例健康足月新生儿骨碱性磷酸酶（BAlp）活性。BAlp活性正常仅27例，可疑佝偻病与临界佝偻病80例。107例中母孕期有小腿抽筋史的新生儿BAlp活性高于无抽筋史的新生儿。经统计学处理，有差异（P＜0.05），说明早期低钙可影响新生儿BAlp活性，骨代谢改变早期有生化指标的异常，BAlp可以作为早期筛查佝偻病的一项敏感指标。提示佝偻病的防治应从围产期开始。

To know the state of neonatal rickets. We detected BAlp in 107 cases fullterm neonatal of good health. BAlp of 27 cases were only normal. 80 cases presented suspect rickets and demarcation line rickets. Among 107 cases BAlp of neonatal with their mothers having a history of leg canvulsion the pregnancy was higher than having no history of leg convulsion (P<0. 05). Difference was found between the two groups. The results showed the Iower level of calcium during the pregnancy affected BAlp of neonatal. There were abnormal biochemical index of bone metalolism in early time.So BAlp couldbe a sensentive diagnostic index in the early detection of neonatal rickets. It also Suggest that prevention and treatment of rickets should begin from perinatal period.