期刊文献+

外层接环糊精的树枝状聚酰胺-胺的合成与表征 被引量:3

Synthesis and Characterization of Novel Polyamidoamine Dendrimer with β-Cyclodextrin on Their Periphery
下载PDF
导出
摘要 研究通过多次重复麦克尔加成和酯的酰胺化两步反应得到不同代数的树枝状聚酰胺-胺(PA-MAM);对β-环糊精(β-CD)采用磺酰化和氨化两步改性反应得到氨化的β-CD衍生物(β-CD-6-E);利用酯的胺解反应,首次将β-CD-6-E接枝到半代的PAMAM表层,得到环糊精修饰的树枝状聚酰胺-胺(PA-MAM-g-β-CD)。通过FT-IR、NMR、DSC、元素分析、动态激光光散射粒度仪等方法对所合成的产物进行了表征。结果表明,合成产物的结构与设计结构吻合,2.5代PAMAM的粒径约为2.13 nm,外层接β-CD后其粒径增大到4.51 nm。 Novel polymer carriers for controlled drug delivery were developed via a combination of polyamidoamine(PAMAM) dendrimers and β-cyclodextrin(β-CD) as external layer. At first, PAMAM dendrimers with generations 1 to 5 were synthesized on the basis of the exhaustive Michael addition and the exhaustive amidation reactions with repeating alternatively. 6-o-Tosyl- β-cyclodextrin (β-CD-6-OTs) was prepared by the reaction of β-CD with p-toluenesulfonyl chloride in the presence of sodium hydroxide using water as the solvent. And β-CD-6-OTs obtained was further aminated by ethylenediamine. The dendrimer derivatives consisting of a dendritic PA- MAM core and β-CD grafts were synthesized by amidation reaction. Their macromolecular structures were characterized by FT-IR, 1H-NMR, βC-NMR, DSC and particle size analyses. The results indicate that the dendrimer derivatives have been synthesized, the particle size of 2.5G PA- MAM dendrimer is about 2.13 nm, and the particle size distribution of PAMAM-g-β-CD is about 4.51 nm. owing to the special structure, the PAMAM-g-β-CD dendrimers may be used as novel controlled polymer drug delivery systems.
出处 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2007年第5期53-56,共4页 Polymer Materials Science & Engineering
基金 国家自然科学基金资助项目(20374040)
关键词 树枝状聚酰胺-胺 Β-环糊精 控释高分子载体 polyamidoamine dendrimers β-cyclodextrin controlled polymer drug delivery carrier
  • 相关文献

参考文献10

  • 1Tomalia D A,Baker H,Dewald J.Polym.J.1985,17:117-132.
  • 2Johnson M A,Iyer J,Hammond P T.Macromolecules,2004,37(7):2490-2501.
  • 3Hu H,Fan X D,Cao Z L.Polymer,2005,46:9514-9522.
  • 4Fukudome M,Fujioka T,Yuan D Q,et al.Tetrahedron Letters,2001,42 (2):293-295.
  • 5Hirayama F,Uekama K.Advanced Drug Delivery Reviews,1999,36:125-141.
  • 6Petter R C,Salek J S,Sikorski C T,et al.J.Am.Chem.Soc.,1990,112:3860-3868.
  • 7Liu Y Y,Fan X D,Gao L.Macromolecular Bioscience,2003,3:715-719.
  • 8Hidetoshi A,Fumihiro K,Fumitoshi H,et al.Bioconjugate Chem.,2001,12:476-484.
  • 9Hirasawa T,Maeda Y,Kitano H.Macromolecules,1998,31(14):4480-4485.
  • 10Masazo N,Tetsuya H,Nobuyuki H.Tetrahedron,2003,59:4011-4015.

同被引文献56

  • 1Helena Dodziuk. Cyclodextrins and their complexes [M]. Weinheim: Wiley Vch Verlag Gmbh & Co. Kgaa, 2006 : 31.
  • 2Jun Li, Xian Jun Loh. Cyelodextrin-based supramolecular architectures: Syntheses, structures, and applications for drug and gene delivery[J]. Adv Drug Delivery Rev, 2008,60 (9) :1000.
  • 3Breslow R,Yang Z, Ching R, et al. Sequence selective binding of peptides by artificial receptors in aqueous solution[J]. J Am Chem Soc,1998,120(14):3536.
  • 4Hirayama F, et al. Cyclodextrin-based controlled drug release system [J]. Adv Drug Delivery Rev, 1999,36(1):125.
  • 5Kumaresh S Soppimath, et al. Microspheres as floating drugdelivery systems to increase gastric retention of drugs [J]. Drug Metab Rev, 2001, 33(2): 149.
  • 6Costas Kaparissides, et al. Recent advances in novel drug delivery systems [J]. J Nano Online, 2006, 2:1.
  • 7Dominique Duchene, Gilles Ponchel, Denis Wouessidjewe, et al. Cyclodextrins in targeting application to nanoparticles [J]. Adv Drug Delivery Rev, 1999, a6(1) :29.
  • 8Lemos-Senna E, Wouessidjewe D, Lesieur S, et al. Preparation of amphiphilie eyelodextrin nanospheres using the emulsification solvent evaporation method. Influence of the surfactant on preparation and hydrophobic drug loading [ J]. Int J Pharm, 1998,170(1) :119.
  • 9Erem Memisoglu, et al. Non-surfactant nanospheres of progesterone inclusion complexes with amphiphilic β-cyclodextrins [J]. Inte J Pharm,2003,251(1-2): 143.
  • 10Erem Memisoglu, Bilensoy A, Atilla Hincal. Sterile, injectable cyclodextrin nanoparticles: Effects of gamma irradiation and autoclaving [J]. Int J Pharm, 2006 , 311(1-2) : 203.

引证文献3

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部