Castleman病的病因研究与治疗现状

Etiology and current status of management of Castleman disease

Castleman病是一种以不明原因淋巴结肿大为特征的慢性淋巴组织增生性疾病。病因可能与病毒感染,血管增生,细胞因子调节异常等有关。近年来学者们更注重对HHV-8感染和IL-6过度表达的研究。治疗方法包括手术切除或放疗,细胞毒化疗药的应用等,近年来不断报道抗CD20单抗和抗IL-6受体单抗治疗CD取得了良好疗效。

The etiology of Castleman disease （CD） was associated with viral infection, angiogenesis, and abnormal modulation of cytokines, etc. The pivotal roles of infection with human herpesvirus 8 and interleukin-6 （IL-6） production in the development of CD are emphasized. Early interventions in the treatment of CD were surgical excision, cytoreductive chemotherapy and radiation therapy. With a greater understanding of CD pathogenesis, monoclonal antibodies therapies such as anti-CD20 and anti-IL-6 receptor monoclonal antibody show great promise.