Obestatin及其生物学效应

Obestatin and its bioactive effects

肥胖抑制素(obestatin)是从大鼠的胃组织中分离出的G蛋白偶联受体GPR39的内源性配体,由胃生长素(ghrelin)基因编码经过翻译后的不同片断剪切和不同类型的修饰后产生的obestatin在调节摄食方面表现出与ghrelin截然相反的作用。Obestatin具有抑制摄食和体质量增加、抑制胃排空和空肠的收缩活动、抑制口渴、影响胰岛素分泌和睡眠等作用。

Obestatin, a newly discovered 2005. Obestatin binds to and activates the orphan peptide, was firstly purified from the rat stomach in G-protein coupled receptor GPR39. Obestatin is derived from the same gene product as ghrelin by differential posttranslational processing and modification, which exerts effects crease body-weight on food intake that oppose those of ghrelin. Obestatin can suppress food intake, degain, inhibite jejunal contraction and thirst, and alter sleep and secretion of insulin.