摘要
探讨氯喹、超氧化物歧化酶(SOD)防治脑缺血再灌注损伤的效果。用4血管阻断法造成大鼠全脑缺血,30min后再恢复双侧颈总动脉血流30min,此时大鼠脑组织磷脂酶A(PLA)活性和内皮素(ET)、过氧化脂质(LPO)含量显著增高,而SOD活性和维生素E(VitE)含量明显降低,大脑皮层神经细胞和血脑屏障明显损害。预防用氯喹或SOD治疗,部分抑制了LPO、ET含量的增高和SOD活性下降,明显减轻脑神经细胞和血脑屏障损伤程度;但对VitE含量都无明显影响。氯喹、SOD对缺血再灌注脑损伤有一定的防治作用。
Protective effects of chloroquine or superoxide dismatase(SOD) on brain of Wistar rats with cerebral postischemic reperfusion was studied. The complete cerebral ischemic models were made by 4 vessel occlusion in awake Wistar rats. By 30 min reperfusion after 30 min complete cerebral ischemia in rats, phospholipase A 2 (PLA 2 ) activities and values of endothelins(ET) and lipid peroxidation(LPO) increased(all P<0.05), but SOD activities and vitamin E(Vit E) Valaues decreased(all P<0.05) in brain tissues. At the same time, Blood brain barriers and cortex neuronal ultrastructures were damaged severely. By pretreatment with chloroquine or SOD, the increases of PLA 2 activities and levels of ET and LPO, the decreases of SOD activities in brain tissue were all inhibited significantly(all P<0.05). At the same time, the cerebral postischemic reperfusion injury was reduced. There were no significant effects on values of Vit E in brain tissue. Effects of chloroquine can partly inhibit PLA 2 activities in brain tissue. Chloroquine and SOD have protective effects on brain in Wistar rat with cerebral postischemic reperfusion.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
1997年第2期84-86,共3页
Journal of Apoplexy and Nervous Diseases
关键词
脑缺血
再灌注损伤
氯喹
超氧化物歧化酶
防治
Postischemic reperfusion Endothelins Free radical Chloroquine Superoxide dismutase