紫花牡荆素体内抗炎作用的研究(英文)

In vivo effect of casticin on acute inflammation

目的:探讨中药蔓荆子中主要成分紫花牡荆素的抗炎作用。方法:通过急性抗炎模型——二甲苯致小鼠耳廓肿胀实验、鸡蛋清致大鼠足跖肿胀实验以及腹腔注射0.7%醋酸致小鼠腹腔毛细血管通透性增高的实验,观察紫花牡荆素的抗炎作用。结果:紫花牡荆素对二甲苯所致小鼠耳廊肿胀、鸡蛋清所致大鼠足肿胀以及醋酸所致小鼠毛细血管通透性增加均有明显的抑制作用。结论:紫花牡荆素具有明显的体内抗炎作用,为蔓荆子抗炎作用的有效成分。

Objective： To investigate the anti-inflammatory effect of casticin of Fructus Viticis. Methods： Observations were made on the anti-inflammatory effect of casticin in the models of acute inflammation in vivo. Results： Casticin inhibited significantly xylene-induced mouse ear edema, egg albumen-induced rat paw edema and acetic acid-induced mouse vascular permeability. Conclusion： Casticin has significant anti-inflammatory effect on acute inflammation, which is probably related to the inhibition of the inflammation factors, Casticin is the effective constituent contributing to the antiinflammatory effect of Fructus Viticis,