宫颈管内滋养细胞用于产前诊断的研究进展

Advance on endocervical fetal trophoblast for prenatal diagnosis

孕早期脱落的胎儿滋养细胞存在于妊娠妇女子宫颈管内,通过对它们的基因组分析可进行各种遗传性疾病的无创性产前诊断,这一发现激起人们的极大兴趣。利用各种方法收集到孕早期妇女宫颈管内的滋养细胞,进行荧光原位杂交或聚合酶链反应,可以检测胎儿性别、非整倍体异常、单基因遗传病等,从而达到早期、简便、无创性产前诊断的目的。

The presence of exutive fetal trophoblast in the endocervical canal of first - trimester pregnancy and their possible use for genomic analysis is still raising great interest for the prospect of a non - invasive prenatal diagnosis of genetic diseases. Retrieving transcervical trophoblastic cells by different methods, analyzing them by fluorescence in situ hybridization or polymerase chain reaction, detecting the sex, the presence of chromosomal aneuploidies or single gene inheritance diseases of the fetus and providing an opportunity to perform early , simple, non - invasive prenatal diagnosis.