多囊卵巢综合征患者的月经改变与血激素水平相关分析

Relationship between menstrual cyclomorphosis and blood hormone in polycystic ovary syndrome(PCOS) patients

目的探讨多囊卵巢综合征(PCOS)患者月经周期改变与血中睾酮、雄烯二酮和胰岛素水平的关系。方法选择临床诊断为PCOS的患者112例,包括继发闭经组(56例)和月经稀发组(56例),采用放射免疫法测定其血清性激素及空腹胰岛素水平,对比两组患者早卵泡期或闭经状态下各项性激素、空腹胰岛素水平及体重指数。结果继发闭经组患者的睾酮、雄烯二酮、空腹胰岛素水平显著高于月经稀发组(P=0.00,P=0.016,P=0.024)结论(1)继发闭经的PCOS患者体内的血清睾酮、雄烯二酮和空腹胰岛素水平明显高于月经稀发的PCOS患者,提示在育龄期继发闭经的P-COS患者有更严重的内分泌代谢失调。(2)育龄期妇女PCOS月经异常程度与体重无直接相关性,但体重指数与高胰岛素血症/高睾酮直接相关,而高胰岛素/高睾酮水平与月经异常程度相干,提示体重对月经异常可能有间接影响。

Objective： To discuss the relationship among menstrual cyclomorphosis, serum testosterone, androstenedione and insulin level in polycystic ovary syndrome （PCOS） patients. Methods： There are 112 PCOS patients including two groups, 56 cases of secondary amenorrhea patients and 56 cases of oligomenorrhea patients, to been tested serum gonad hormone in blood and fasting insulin by radio - immunity method. Their values of gonadal hormone, insulin and baric index of early follicular phase patients or amenorrhea phase were compared. Results ： The values of testosterone and androstenedione in blood serum, fasting insulin of secondary amenorrhea patients are higher than oligomenorrhea patients. （P =0. 00, P =0. 016, P =0. 024） Conclusion： The values of serum testosterone and androstenedione, fasting insulin of secondary amenorrhea patients are higher than oligomenorrhea patients. During child - boating period, the secondary amenorrhea PCOS patients have serious endocrine secretion metabolic disorder.