姜黄素防治大鼠高脂血症致肾脏损害的实验研究

Experimental Study on Curative Effect of Curcumin in Preventing and Treating Renal Injury Caused by Hyperlipemia

目的:探讨姜黄素防治大鼠高脂血症致肾脏损害的作用。方法:喂食高脂饲料(膏粱厚味)造成大鼠高脂血症致肾脏损害模型,姜黄素(高、中、低剂量)同时干预给药,分别检测血脂(TG、TC、HDL-C、LDI-C)、血液流变学、24h尿蛋白量、尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)、肾功能(Scr、BUN)、肾组织病理(肾脏指数、系膜基底膜面密度、毛细血管襻面密度)。结果:姜黄素能改善高脂血症大鼠TC、TG、LDL-c、全血黏度、血浆黏度,并能降低尿蛋白量、尿NAG、肾脏指数、系膜基底膜面密度,提高毛细血管襻面密度,呈现量效依赖关系。结论:姜黄素能防治大鼠高脂血症致肾脏损害,以高剂量姜黄素作用最为显著。

Objective： The study here aims to explore the curative effect of curcumin in preventing and treating renal injury caused by hyperlipemla. Methods： Make the rats model of renal injury caused by hyperlipemia by feeding high - lipid forage ,meanwhile ,intervene by administering eurcumin at high, medium and low dosage. After the experiment, respectively test serum lipid （ TG,TC, HDL - C and LDL - C） , blood rheology, 24 - hour urinary protein, urine - N - aeetyl - β- D - glucosaminidase （ NAG）, kidney function （ Scr, BUN ）, kidney pathology （ kidney indexes, density of mesangium and basilarmembrane, density of capillary loop. ） Results： The eureumin can improve TC, LDL- C ,TG, whole blood mueosity and the plasma mueosity, reduce urinary protein, urine - N - aeetyl - β - D - glueosaminidase （NAG） , kidney inde- xes, density of mesangium and basilarmembrane,increase density of capillary loop of the rats with hyperlipemia,in a dose -effect relationship. Conclusion： The eureumin can prevent and treat the renal injury cause by hyperlipemia, especially the eureumin in the high dosage group showing best.