银杏内酯B对AD模型大鼠学习记忆的影响

Effects of Ginkgolide B on the learning and memory ability of the model rats of Alzheimer′s disease

目的:观察银杏内酯B对AD模型大鼠学习记忆的影响。方法:采用IBO损毁大鼠双侧Meynert基底核(NBM),建立AD动物模型,治疗组用不同剂量的银杏内酯B连续腹腔注射20 d,做跳台实验和Y迷宫实验,测试大鼠的学习记忆能力。结果:银杏内酯B治疗组较模型组学习记忆能力显著增强(P<0.01或P<0.05)。结论:银杏内酯B可提高AD模型大鼠的学习记忆能力。

Objective： To test the effects of ginkgolide B（GB） on learning and memory ability of Alzheimer＇s disease （AD） model rats. Methods： AD animal model was established by microinjecting IBO （5 μg） into bilateral NBM of rat to damage them. GB at different concentrations was injected intraperitioneally in the GB rats for 20 days. 20 days later, the learning and memory ability were tested using jumping table experiment and Y- maze experiment. Results： Compared with model group, the learning and memory abilities of GB groups were significantly improved. （P 〈0. 01 or P 〈0. 05）. Conclusion： Ginkgolide B can improve the learning and memory ability of the model rats of Alzheimer＇s disease.