我院2004年～2006年院内获得性肺炎致病菌分析

Pathogens and drug resistance in patients with hospital acquire pneumonia

目的了解医院获得性肺炎致病菌的分布特点及耐药性,有利于早期经验性使用抗生素。方法分析2004年1月～2006年4月医院获得性肺炎患者114例,自患者痰液分离致病菌,并分析药敏试验结果。结果痰培养分离出致病菌依次为金黄色葡萄球菌、嗜麦芽窄食单胞菌、粪肠球菌、阴沟肠杆菌、铜绿假单胞菌。对革兰氏阴性杆菌耐药率小的抗生素依次为亚胺培南（32.8%）、阿米卡星（32.8%）、氨曲南（53.3%）;对革兰氏阳性球菌抗菌耐药率小的抗生素依次为万古霉素（15.4%）、四环素（54.1%）、亚胺培南（58.9%）。结论万古霉素、亚胺培南、阿米卡星是治疗耐药菌感染的强效药物。

Objective To study the features of isolated bacteria from sputum specimens in patients with hospital acquired pneumonia（HAP）. Methods The bacteriology of patients with HAP between Jan.2004 and Apr.2006 were analyzed.Results The five most common isolated bacteria were Staphylococcus aureus,Steotrophomonas maltophilia,Eenterococcus faecalis,Enterobacter cloacae,and Pseudomonas aeruginosa in patients with hospital acquire pneumonia with MODS（n=114）.The active agents against gram negative organisms were imipenem,amikacin,aztreonam.Vancomycin,tetracycline,imipenem were active of the Gram positive bacillus.Conclusion Vancomycin,imipenem,amikacin were main choice to patients with HAP.