TGF-β和P53在肾细胞癌中的表达及意义

Expression of TGF-beta and P53 in Renal Cell Carcinoma

目的:通过检测转化生长因子-β(TGF-β)和P53在肾细胞癌(RCC)中的表达,探讨它们与肾癌的发生、病理分级、临床分期的关系。方法:免疫组织化学方法检测40例RCC石蜡标本中TGF-β和P53的蛋白表达,并分组进行统计学分析。结果:TGF-β与P53在RCC中表达率与对照组相比明显升高(P<0.05),但不同病理分级、临床分期之间差异无显著性(P>0.05)。TGF-β和P53表达存在正性相关,但两者在RCC中表达率存在显著性差异,TGF-β表达率高于P53的表达率(P<0.05)。结论:TGF-β和P53高表达可能成为肾癌的恶性表型之一,但两者与病理分级、临床分期无明显相关性。它们可能单独或协同作用调节细胞生长和转化,促进肾癌的发生。

Objective： To investigate the expression renal cell carcinoma（RCC）. Methods： Protein of transforming growth factor-β（TGF-β）and P53 in expression of TGF-β and P53 in 40 RCC tissues was examined by immunohistochemical assay. Results： TGF-βand P53 showed an overexpression rate in RCC,but there were no significant differences among different pathological grades and clinical stages. A positive correlation was detected between TGF-β and P53, but the expression rate of TGF-β was higher than that of P53. Conclusion： Both the expression of TGF-β and P53 were malignant phenotypes in RCC,but there are no correlation at different pathological grades and clinical stages. Both may regulate cell growth and transformation for the occurrence of RCC solely or coooeratively.