晚孕铁缺乏症中胎盘TGF-β_1的异常表达

Expression of TGF-beta1 in the Placenta of Pregnant Women with Iron Deficiency in the Third-Trimester

目的:研究晚孕妇女铁缺乏症的发生情况,探讨孕妇胎盘TGF-β1的异常表达与铁缺乏症之间的联系。方法:根据血红蛋白(Hb)水平的不同各选取20例孕足月妇女定为A组(100-105 g/L)、B组(105-110 g/L)、C组(Hb≥110 g/L)。分别测定母血血清铁蛋白(SF)水平,依铁蛋白水平划分铁缺乏症组和正常组,分别对其胎盘TGF-β1的表达进行半定量分析。结果:C组铁缺乏症的发生率低于其它两组,差异有显著性(P<0.05);铁缺乏症组胎盘TGF-β1的阳性表达率为68.42%,高于正常组,差异有显著性(P<0.05)。结论:通过对母血血清铁蛋白的测定可以了解体内的贮铁水平;将正常孕妇血红蛋白值评判标准由以往的>100 g/L提高为>110 g/L,有利于及时发现和治疗铁缺乏症的孕妇。胎盘TGF-β1升高引起滋养细胞浸润不足可能是妊娠期缺铁性贫血继发病理妊娠的发病原因之一。

Objective： To study the serum ferritin （SF） changes in the ghird-trimester, and to analysis expression and significance of TGF-β1 in the placenta of pregnant women with iron deficiency （ID）. Methods： All the 60 pregnant women in the third trimester were divided into three groups according to the level of haemoglobin （Hb） as group A （100-105 g/L）, B （105-110 g/L） and C （〉110 g/L）. The SF level of mothers was measured by using chemiluminescent immunoassay （CLIA）. The SP immunohistochemical method was performed to determine the location and intensity of TGF-β1 expression in placenta tissues of 60 patients. Results： The expression level of TGF-β1in placenta significantly increased in ID groups compared with that in the normal group. Conclusion： The detection of SF level of mothers was helpful in determining the stored iron level. Improvement of the diagnosis standard of Hb in normal pregnant women from 100g/L to 110 g/ L could be of value in the diagnosis and treatment of ID patients. The elevated expression of TGF-β1 in placenta leads to the deficiency of trophoblast cell invasion, which may be one of the causes of pregnancy with anemia.