(-)-1R,2S,5R-8-(4-甲氧基甲基苯)薄荷醇的合成表征

The synthesis and characterization of (+)-1S,2S,5R-8-(4-methoxymethyl)menthol from R-(+)-pulegone

以R-(+)-长叶薄荷酮为起始原料,经1,4-加成、还原两步反应合成了手性辅助试剂(-)-1R,2S,5R-8-(4-甲氧基甲基苯)薄荷醇及其反向异构体(+)-1S,2S,5R-8-(4-甲氧基甲基苯)薄荷醇,总产率88%。其结构用1HNMR和13CNMR进行了表征。

The chiral auxiliary（-）-1R,2S,5R-8-（4-methoxymethyl）menthol was synthesized by the 1,4-addition and reduction reaction using R-（＋）-pulegone as the starting material.The overall yield of the title product was 88%.The structure of the chiral auxiliary was characterized by ^1HNMR and ^13CNMR.