不同呼气末正压水平对呼吸窘迫综合征早产儿通气效率的影响

Influence of Different Positive End Expiratory Pressure Level on Ventilative Efficiency for Premature Infant with Respiratory Distress

目的探讨不同呼气末正压(PEEP)水平对早产儿通气效率的影响。方法需机械通气肺透明膜病早产儿40例,随机分为低PEEP(0.49～0.59kPa)、高PEEP(0.59～0.78kPa)组进行机械通气,并予肺表面活性物质(PS)干预,上机稳定后15min,2、6、12、24h采集动脉血和血气分析,计算pa(O2)/FiO2比值、氧合指数和通气效率。结果低PEEP组pa(O2)/FiO2比值、氧合指数和通气效率均优于高PEEP组(Pa<0.05)。结论呼吸窘迫综合征早产儿在接受PS后,低PEEP(0.49～0.59kPa)机械通气更为合适。

Objective To explore influence of different positive end expiratory pressure（PEEP）level on ventilative efficincy of premature infant with respiratory distress syndrome（RDS）.Methods Forty preterm infants who were diagnosed RDS and needed ventilation were randomly assigned to lower PEEP（0.49-0.59 kPa）and high PEEP（0.59-0.78 kPa）group.They were treated by ventilation and pulmonary surfactant（PS）.When they were medically stable,blood gas was done at 15 min,2,6,12,24 h after ventilation.Then the ratio of pa（O2）/FiO2,oxygen index（OI）,ventilation index were calculated.Result The ratio of pa（O2）/FiO2,OI,ventilation index were better in lower PEEP group than those in high PEEP group（Pa〈0.05）.Conclusion Lower PEEP is better in neonatal RDS with ventilation and PS.