163例外周T细胞淋巴瘤-非特指型患者的临床特征及预后分析

Clinical Characteristics and Treatment Response of 163 Patients with Peripheral T-cell Lymphoma Unspecified

目的:阐明中国人群中外周T细胞淋巴瘤-非特指型(PTCL-U)患者的临床特征,并探讨其与预后的关系。方法:回顾性分析2002年1月～2006年12月期间收治的初治PTCL-U患者163例,分析其临床特征,采用卡方检验(Chi-square test),比较不同临床特征与完全缓解率之间的关系。结果:PTCL-U患者的中位年龄39岁;男女比例为2.4:1;74.85%的患者有结外侵犯,最常见的结外侵犯部位是咽淋巴环(鼻咽、扁桃体和软腭);完全缓解率43.56%;Ⅲ～Ⅳ期、乳酸脱氢酶高、出现结外侵犯、体能状况差、巨大包块者完全缓解率低;性别、年龄、B症状及是否放疗与完全缓解率无显著性相关;国际预后指数(IPI)不同的患者,其完全缓解率有显著性差异。结论:中国人群中PTCL-U常发生于年轻男性患者,大部分患者伴有结外侵犯,完全缓解率低,可以利用IPI指数预测其疗效与预后。

Objective：To analyze the clinical characteristics and treatment response of 163 cases with peripheral T-cell lymphoma unspecified（PTCL-U）and to explore the association between its clinical characteristics and prognosis.Methods：163 cases with PTCL-U treated between January 2002 and December 2006 in Guangxi Cancer Hospital were retrospectively analyzed.The association between clinical features and the probability of attaining complete remission（CR）was evaluated by Chi-square test.Results：The median age of patients was 39 years,and the male-to-female ratio was 2.4：1.The extranodal involvement rate was 74.85% and Waldeyer＇s ring was the most frequent site.The CR rate was 43.56% and the factors associated with a lower probability of achieving CR were advanced disease（stage Ⅲ-Ⅳ）,the presence of extranodal involvement,poor performance status（PS）,high LDH levels,bulky disease and International Prognostic Index（IPI）.Conclusion：There is a preponderance of males and a low CR rate in cases with PTCL-U.IPI is shown to be of highly significant prognostic value.